It’s unsurprising that the AIDS epidemic has been notably absent from Fantasy and Science fiction novels. There are lots of reasons for this: many read for escapism, the 80s/90s isn’t a common time period for fantasy or science fiction in general, and AIDS doesn’t fit neatly into the cute love story narrative that traditional publishers have historically leaned on when writing books about gay men. Things are improving – traditionally published trans protagonists exist, though they’re still rare – and there are a few novels that have tackled the idea (though I couldn’t bring myself to keep reading the train wreck that was Disco Witches of Fire Island). I live in hope, but my hopes aren’t very high.
Comics have actually done a much better job of engaging with the topic, though not always well. I got to teach a few lessons on the representation of AIDS in superhero comics a few years ago, and I’m hoping I’ll have the chance to expand it into a full unit soon. Barbalien was part of that journey, and a great example of how mainstream comics have evolved on the issue over 30 years. Barbalien is set in the The World of Black Hammer, a superheroverse more or less analogous to DC or Marvel. You really don’t need any previous context for the story, so don’t feel like you need to jump in ‘at the start’ if you aren’t interested in the cute and satirical set of villain interviews that form the universe’s first installment. Barbalien is a more serious story, but not so bleak as to suffer accusations of torture porn.
Finally, it’s important to note that while Jeff Lemire seems to be listed as the main author, the story is a collaboration between him and Tate Brombal. The actual script (dialogue, panel by panel story descriptions, etc) is all Brombal, an openly gay comic writer.

Read If Looking For: queer joy, queer pain, and queer love
Avoid If Looking For: sympathetic cops, cinematic fight scenes, fleshed out supporting characters